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Combined with other internal sources of oxidative stress, like inflammation and psychoemotional stress, and external sources, like ultraviolet radiation, we get a buildup of oxidative stress over decades that may cause our melanocytes, the pigment-producing cells, to age and die off

The point is to make it more complete

A diagnosis of GSSD was finally made based on intractable metabolic acidosis, jaundice, hemolytic anemia, hyperbilirubinemia, massive 5-oxoprolinuria, and the presence of compound heterozygous variants in GSS

When telomerase is upregulated and telomeres are better maintained, cells are less likely to shift into premature old age mode, and chromosomes remain more stable during division