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Metformin is associated with glycemic control failure in a substantial proportion of adolescents, while insulin therapy can lead to hypoglycemia and weight gain

Headache, fatigue and dizziness represent additional common but usually mild side effects

How to Switch Your Injection Time Safely If you have been injecting in the morning and want to move to the evening, or if you want to change your injection day entirely, you can do so safely as long as you follow the 48-hour rule. According to the guidelines for most semaglutide-based medications, you can change the day or time of your weekly injection as long as the time between two doses is at least 48 hours (2 days)