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Shared mechanistic pathways of glucagon signalling: Unlocking its potential for treating obesity, MASLD, and other cardio-kidney-metabolic conditions (Diabetes, Obesity & Metabolism)
Due to its roles in such a broad array of systems, targeting the ghrelin receptor with agonists or antagonists will not only affect the phenomenon of interest, such as feeding, but will also affect the other systems in which ghrelin is involved, leading to unwanted side effects
Answer: Good candidates are adults struggling with persistent hunger, a stalled response to GLP-1 medications, insulin resistance, or a long history of weight cycling, who want to address the hormonal driver of appetite rather than rely on restriction alone
This can lead to inflammation and "follicle miniaturization," where the hair grows back thinner and shorter with each cycle
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