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Although extracellular vesicles, oxidized phospholipids, secreted proteins, and lipid-derived electrophilic metabolites all represent plausible candidates, it remains unclear which mediators possess sufficient stability and diffusivity to support propagation across anatomically separated yet functionally connected cells

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Kuah E, Toh S, Yee J et al (2016) Enzyme mimics: advances and applications

Wound Repair Regen 2 (4): 259269