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6.2 NADPH: driving force for glutathione redox cycling The antioxidant activity of glutathione (GSH) critically relies on its regeneration from the oxidized form, glutathione disulfide (GSSG), through a reaction catalyzed by glutathione reductase (GR) that consumes NADPH
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N-acetylcysteine (NAC) is the most well-established precursor, supplying cysteineoften the rate-limiting amino acid in glutathione production
Saavedra-Bonilla H, Varman DR, ReyesHaro D (2024) Spontaneous calcium transients recorded from striatal astrocytes in a preclinical model of autism
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