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To date, only few studies have examined the effects of LC supplementation for at least 12 weeks, which is, on the other hand, the main limitation of the current review

Eligibility is BMI 35 or higher, or BMI 27 or higher with a weight-related comorbidity such as cardiovascular disease, prediabetes, or hypertension

[Glutathione conjugation reactions: metabolic inactivation and activation of carcinogens and other toxicants by glutathione S-transferases]

Elevated lactate concentrations within the tumor microenvironment can activate GPR81 receptors located on the cytoplasmic membrane of cells, subsequently facilitating MCT1-mediated lactate uptake (57,58)