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Pharmaceutical Biology, 55 (1), 663672
Semaglutide works by mimicking the GLP-1 hormone to regulate blood sugar and reduce appetite, while retatrutide mimics three hormonesGLP-1, GIP, and GCG to potentially offer more comprehensive benefits for weight loss, blood sugar control, and metabolism
GLP-1 receptors (GLP-1R) are found in the hypothalamus, (which is vital for functions for the regulation of body temperature, hunger, thirst, sleep-wake cycles, and emotions), the brain stem and the mesolimbic system (a key neural circuit that plays a central role in motivated behaviours, reward processing, and emotional regulation)
According to experts, the new drug may be particularly helpful for people with significant obesity or type 2 diabetes, or with conditions like MASH, osteoarthritis, and sleep apnea
