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Clinical trials of GLP-1-based therapies commonly exclude individuals with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2 (MEN2) on the basis of preclinical thyroid C-cell findings

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Tier 4: Medical Intervention (When Indicated) Clinical obesity, type 2 diabetes, or other metabolic conditions requiring pharmaceutical management represent appropriate medical intervention contexts

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