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Clin Pediatr Endocrinol
However, when HepaRG stem-cell derived human hepatocytes were subjected to APAP, the same mechanisms of hepatotoxicity were demonstratedstarting with GSH depletion and moving through protein adduct formation, superoxide and peroxynitrite formation and lysosomal iron uptake into mitochondria
Then, Sf9 cells were co-expressing Pelo-Flag with ubiquitin-WT-HA or ubiquitin-K48-HA, or triply expressing Pelo-Flag, ubiquitin-WT-HA/ ubiquitin-K48-HA and E3-Myc for two days
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