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They come up in longevity and body-composition clinics, which is a different use case

Therefore, inhibiting glutathione production or function has proven effective in reversing drug resistance [31, 51]

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in macrophages this axis can constrain inflammatory glycolysis and inflammasome activity, whereas in T cells it supports mitochondrial fitness and persistenceprocesses that appear perturbed after major surgery ( Beta-hydroxybutyrate (BHB), a ketone body, is another interesting example BHB directly inhibits the NLRP3 inflammasome by preventing K + efflux and possibly via activation of the hydroxycarboxylic acid receptor 2 (HCA2) on immune cells (121, 122)