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Ongoing monitoring typically involves monthly or quarterly check-ins during dose titration, regular assessment of weight loss progress and tolerability, periodic lab work to monitor metabolic parameters, and screening for potential complications
Additionally, a greater proportion of patients in the later period had no previous type 2 diabetes drug classes in the 180 days prior to and including the index date
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A GLP-1R agonist (liraglutide) increased endothelial nitric oxide synthase phosphorylation and nitric oxide (NO) production by the 5-AMP-activated protein kinase (AMPK)-dependent pathway and subsequent NO production in cultured HCAEC [56],[57]
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