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OTA reduces the expression of several genes regulated by nuclear factor-erythroid 2 p45-related factor (Nrf2) and reduces the expression of antioxidant enzymes through inhibition of Nrf2 [62, 63]

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In a separate analysis involving re-estimation of the model using data from a trial in subjects with T2D with or without upper GI disease [21], oral semaglutide PK were found to be similar between healthy subjects and subjects with T2D with or without upper GI disease