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2 Noxygen 2-5
Recent studies have shown that increased ROS production promotes reversible uncoupling of NO synthase (NOS) and shifting the enzyme activity to produce more ROS instead of NO [51], [52]
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Alternative and emerging therapies for severe alcohol-associated hepatitis Abbreviations AAH alcohol-associated hepatitis ALD alcohol-associated liver disease CYP-450 cytochrome P450 enzyme system DAMPs damageassociated molecular patterns ELAD extracorporeal liver assist device FMT fecal microbiota transplant G-CSF granulocyte colony stimulating factor INR international normalised ratio MDF Maddreys discriminant function MELD model for end-stage liver disease PAMPs pathogen-associated molecular patterns RCT randomized controlled trial SAH severe alcoholassociated hepatitis TNF- tumor necrosis factor alpha REFERENCES 1
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