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By improving metabolic fitness before overt disease emerges, GLP-1 therapies prevent a wide range of complications

It was impressive to see that every dose of retatrutide resulted in clinically meaningful weight reduction for nearly all participants, and people with severe obesity on the highest dose lost on average 30% of their body weight over two years, lead investigator Ania Jastreboff, MD, professor of medicine and pediatrics at the Yale School of Medicine and director of the Yale Obesity Research Center, said in a press release

Semaglutide works by slowing stomach emptying and activating appetite-control centers in the brain, leading most patients to eat between 1,200 and 1,800 calories daily without deliberate calorie counting

These reactions were generally self-limited and resolved without intervention