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GLP1/E improves metabolic and gonadal traits in a PCOS model of ovarian dysfunction We next assessed the metabolic, gonadal, and hormonal effects of the intervention with equivalent doses (10 nmol/kg) of GLP1, E, or GLP1/E in PNA mice, which retain ovulatory capacity albeit with clear dysregulation of ovarian cyclicity

This supports prioritizing GLP-1RA over insulin in patients requiring intensive glycemic control, potentially offering additional hepatoprotective benefits (Yang et al., 2024)

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