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Starting weight loss therapy with uncontrolled hypothyroidism may: Confound assessment of treatment efficacy Complicate symptom attribution (fatigue, constipation overlap) Necessitate multiple medication adjustments simultaneously Practically speaking, patients may benefit from demonstrating stable thyroid function on consistent levothyroxine dosing before adding weight loss medications, though this is not a strict requirement

Lilly reported producing more than 1.6 times the salable incretin doses in the first half of 2025 compared to the same period in 2024, with plans for significant additional manufacturing expansion [39]