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The risk of NAION needs to be taken into account and may help to decide about a more conservative approach in the definition of beginning semaglutide for those subjects without a clear indication for that. When looking at the results of these studies, Bert said its important to note that when looking at the increases of percentages, it demonstrates that it is still very, very rare for a condition like NAION to occur

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It might also increase the severity of some neurological symptoms like seizures, and may interact with some anticoagulants such as warfarin