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Risk 2: Amplified gastrointestinal distress Tirzepatide GI side effects and alcohol GI effects are not simply additive

These could be signs of a very serious health problem called an upper gastrointestinal bleed, or it might indicate a bleeding disorder such as thrombocytopenia (a condition where you have a lower-than-normal number of platelets in the blood, leading to excessive bleeding) or anticoagulant toxicity (a dangerous reaction to medications that prevent blood clotting).

Keep in mind, that semaglutide may be a better option for you if you have heart disease