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These alternatives present needle-free options with comprehensive clinical validation, unlike compounded oral tirzepatide products
Importantly, steatosis does not seem to cause a parallel resistance to the hyperglycaemic effects of glucagon (with glycogenolysis taking place mainly in the central part of the liver acinus and amino acid metabolism taking part in the portal end), so hyperglucagonaemia still contributes to diabetes-associated hyperglycaemia [42, 43]
Data availability Uncropped western blot images are provided in Supplementary Fig
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