This damage can result in mutations within oncogenes such as RAS and MYC, as well as tumor suppressor genes like p53 and PTEN, thereby fostering genomic instability and malignant transformation [31, 32]
In recent times, these drugs have become hugely popular for weight loss purposes, boosted by social media and celebrity endorsements
Ferroptosis, an oxidative stress-dependent regulated cell death modality, is potently triggered by oxidative stress, a mechanism particularly critical in ocular pathologies (159).Accumulating evidence implicates ferroptosis in retinal neurodegeneration and DR pathogenesis, supporting oxidative stress as a central bridge linking ferroptosis to DR progression (160, 161)
it was the sense of control I felt returning." For Mary Joye, a therapist and life coach, one of her struggles was dealing with food noise constant, intrusive thoughts about food