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As underling mechanism of the interaction between afferent and efferent renal nerves our previous report [24] has shown that activation of afferent renal nerves leads to activation of efferent renal sympathetic nerves response to GLP-1, possibly via central neural reflex in normal rats

"We have supported GPs to contact all patients currently prescribed these drugs to advise them that they should continue to take their medication as normal, and that they will be contacted by their GP practice if their diabetes treatment needs to be reviewed as a result of these shortages

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To demonstrate the influence of the peptide sequence on the proposed cyclization, we followed the reaction workflow using different hexapeptides (Fig