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GLP-1R activation can downregulate pro-inflammatory mediators and shift macrophage phenotypes toward anti-inflammatory profiles [15,16,17]
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"Their main side effects are usually nausea and vomiting." In TRIUMPH-2, up to 11.6 percent of participants using retatrutide stopped the drug before the end of the trial due to side effects, compared with 4.9 percent of the placebo group
