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In one study of 208 patients, 45 experienced 88 fractures, with Standardized Incidence Ratios (SIRs) of 2.9 in females and 3.4 in males

Full-strength lactic acid (LA) solution, in concentrations of 92% or 82%, was reported in two studies as an alternative to be applied with gloved fingers just over the lesional area and removed after erythema or stinging

The meetings are typically a forum for debate over products that have raised questions for FDA reviewers, and the agency historically has almost always accepted the advice of the experts