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The uptake of EVs by glial cells and neurons can occur through specific membrane receptors, such as the phosphatidylserine receptor T-cell immunoglobulin and mucin domain containing 4 (TIM4), which may contribute to cellular activation and modulation of neuroinflammatory responses [261, 262]
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Ozoralizumab, a humanized anti-TNF NANOBODY compound, exhibits efficacy not only at the onset of arthritis in a human TNF transgenic mouse but also during secondary failure of administration of an anti-TNF IgG
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