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The gut microbiota plays a crucial role in host physiology, influencing the gut-brain axis and metabolizing dietary components into compounds like TMAO

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As discussed in the section on EGT in mycobacteria, disruption of two different genes ( egtA or egtD ) in the Mtb EGT biosynthetic pathway significantly reduced the intracellular survival of Mtb in macrophages after 5 days, demonstrating that EGT is essential for intracellular survival in macrophages (52)