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Total weight loss at 48-68 weeks on the combination is difficult to predict without clinical trial data, but based on individual compound data (retatrutide at 24-28.7% and the additive benefit seen with CagriSema), a reasonable estimate for the combination is 25-35% total body weight reduction in high responders

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JAMA Network Open, 9(5), e2612133

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animals." It is suggested to be involved in cellular repair and regeneration processes as well

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You still want to have a slow, steady weight loss with slow dose titration

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