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Additional risks include diabetic retinopathy complications (particularly with semaglutide in patients with pre-existing retinopathy), acute kidney injury (especially with volume depletion from gastrointestinal effects), and rare cases of intestinal obstruction or ileus
(2025) 86:e70044
Day 1-2 (Acute Detoxification) Internal systemic detoxification biologically peaks
Instead, evidence-based approaches supported by NICE include: Structured lifestyle programmes combining dietary advice and increased physical activity (NICE PH53) Behavioural interventions delivered by trained practitioners Pharmacological treatment prescribed and monitored by a GP or specialist, such as: Orlistat (Xenical 120 mg on prescription
