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I think of this as more of a relief than a burden, Salas-Whalen says

Consequently, tissue-level outcomes may depend not only on receptor activation but also on the availability of metabolic substrates required to sustain bioenergetic and redox balance under conditions of reduced nutrient inflow

DPP-4 inhibitors (dipeptidyl peptidase-4 inhibitors) like sitagliptin, linagliptin, or saxagliptin provide moderate glucose-lowering with minimal gastrointestinal side effects and are weight-neutral