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Oncogenic myc induces expression of glutamine synthetase through promoter demethylation
When both are supported, they form a complementary, two-layer system that helps protect cells while powering efficient metabolic function
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Of 127 cases with follow-up in Woodruff and Senies review (34), 43% had regional lymph node metastases, 22% had metastases to skin or subcutaneous tissues, and 44% had distant spread
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