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This significantly elevates Angiotensin II (Ang II) levels, a key RAAS mediator, which induces intestinal epithelial injury through four main pathways: (1) Ang II selectively inhibits P-glycoprotein (Pgp) function and membrane expression in intestinal epithelial cells via AT1 receptor-mediated PI3K/Akt-p38 MAPK signaling

Over an extended period of time, stress can make us more vulnerable to depression by making us feel overwhelmed and even changing our biology

Tomas FM, Knowles SE, Owens PC, Chandler CS, Francis GL, Read LC, Ballard FJ