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Case reports and small open-label use in clinics pop up online, but without standardized outcome measures, no control groups, and no objective biomarkers

In 2015, an expert panel convened by the US National Toxicology Program and the US Office of Dietary Supplements concluded that folic acid supplementation does not reduce cancer incidence in folate replete individuals and that further research is needed to determine whether supplemental folic acid might promote cancer growth (122)

Similarly, mice repeatedly exposed to phencyclidine demonstrated attenuated cognitive deficits when pretreated with a GR-containing diet (~2.3 mol/kg) (51)