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In other words, semaglutide engaged Alzheimers biology but not strongly enough, or early enough, to translate into clinical benefit as a stand-alone therapy

Plasma DPP-4 activity, glucose tolerance, body weight, plasma active GLP-1, and TG levels were not different in RC-fed Dpp4 Gut/ mice, whether examined in the fasting state or following olive oil gavage (Figure 2, G and H, and Supplemental Figure 1, G and H)

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