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Antioxidants 9 (11), 1168

While they found better skin outcomes in participants who used hydroquinone cream (a common melasma intervention), they also concluded that topical silymarin was also effective and produced fewer side effects.28 Wrinkles A lack of skin moisture is one of the factors behind fine lines and wrinkles.29 According to a 2012 study published in the African Journal of Biotechnology , milk thistle extract, emulsified into a topical cream, may help combat wrinkle formation by boosting moisture retention and preventing transepidermal water loss.30 An important caveat to consider is that all of our top recommended milk thistles are oral supplements, and research on oral milk thistle for the above purposes is somewhat lacking

Both have specific medical indications and require a prescription. However, some weight loss clinics and med spas offer lipotropic injections without a prescription, but the ingredients are unregulated

The meeting was well-attended with ~500 participants from research, industry, and government