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Knockdown of SHMT2 in T315-Bcr-Abl-32D cells led to about 50% reduction in dTTP pool in these cells (Fig
We treated human TC cells (K1, MDA-T68, MDA-T32, TPC1) with (1S,3R)-RSL3 (RSL3), a small-molecule inhibitor of GPX4 and examined the effects on ferroptosis, tumor cell survival and migration, spheroid formation, oxidative stress, DNA damage repair response, and mTOR signaling pathway in vitro
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