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The GLP-1 receptor (GLP-1R) is an established drug target for the treatment of diabetes and obesity 2 , whereas the therapeutic potential of the GIP receptor (GIPR) is a subject of debate
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This study establishes a patterned iPSC-derived sensory neuronal circuitry between DRG organoid (DRGO) sensory neurons and muscle intrafusal fibers, offering an improved in vitro model for studying FRDA pathology and investigating potential therapeutic interventions, such as CRISPR/Cas9-mediated removal of trinucleotide expansions in the FXN gene intron
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