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And while in most people with HIV traditional risk factors are driving their fatty liver disease, we do think there is a component of liver disease that is HIV specific, so some of those secondary effects of semaglutide may have unique benefits in people with HIV. Lake and colleagues enrolled 49 adults with MASLD and HIV into the open-label phase 2b SLIM LIVER study

PMC 4113679

As expected, positive control analyses showed lower risks of major adverse cardiovascular events and major adverse kidney events among GLP-1 RA initiators relative to DPP-4i initiators, whereas negative control outcomes (glaucoma and bone fracture) did not differ between groups ( Supplementary Table 2 )

Penovich PE, Buelow J, Steinberg K, Sirven J, Wheless J