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TMAO can change the bile acid spectrum to accelerate the formation of aortic lesions in ApoE / mice, and further activate the nuclear receptors farnesoid-X-receptor (FXR) and small heterodimer partner (SHP), to reduce the expression of cholesterol 7-hydroxylase (Cyp7a1) to inhibit bile acid synthesis, thus accelerating the formation of atherosclerosis (82)
We conclude that creatine supplementation reduces plasma Hcy levels and lipid peroxidation biomarkers, suggesting a protective role against oxidative damage
Publisher | Google Scholor Otten BMJ, Sthijns MMJPE, Troost FJ
Lastly, aged males demonstrated changes in gene expression connected with the downregulation of several behavioral responses (Fig
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