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Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China J Chin Mater Med 45(8):18511858 Lin Y, Li X, Huang L, Xie X, Luo T, Tian G (2024) Acupuncture combined with Chinese herbal medicine for discogenic low back pain: protocol for a multicentre, randomised controlled trial

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* **Naltrexone/Bupropion (Contrave):** Carries an **FDA Boxed Warning** for increased risk of suicidal thoughts and behaviors associated with antidepressants (bupropion component)

demonstrated that although the combination therapy (metformin 1000 mg BID + liraglutide 1.2 mg/day) resulted in a greater weight loss than liraglutide alone, both groups showed an increase in SHBG and a decrease in free testosterone, with no differences between the two treatment arms, thus suggesting that the effect on the biochemical hyperandrogenism of liraglutide may be partially independent of the extent of weight loss [60]