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Common side effects reported with retatrutide include: Nausea, vomiting, and diarrhoea (most frequent, particularly during dose escalation) Decreased appetite Constipation Injection site reactions Mild increases in heart rate Cagrilintide has demonstrated a generally well-tolerated profile, with gastrointestinal symptoms also being the most commonly reported adverse effects

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Many peptides (especially those containing Asp or Asn residues) are prone to specific degradation pathways like deamidation or hydrolysis at certain pH ranges

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