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Patients with a history of diabetic retinopathy should be monitored for progression of diabetic retinopathy during treatment

"Maternal vitamin B12 status and risk of neural tube defects in a population with high neural tube defect prevalence and no folic Acid fortification"

These limitations do not invalidate preclinical findings but emphasize the need for human clinical trials with appropriate sample sizes, standardized protocols, and validated outcome measures before establishing clinical efficacy in human patients

The therapy is known for having minimal to no side effects, making it a safe choice for most individuals