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Fecal matter from metformin-treated mice attenuates intestinal ferroptosis induced by IIRI To investigate the role of the gut microbiota in the anti-ferroptosis effect of metformin, we established a dirty cage group by allowing mice to feed on metformin-modulated feces from the MET group

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One recent study found that staged excision was associated with a significantly lower recurrence rate than Mohs, and there were no differences in the final size of the surgical defect.51 This technique, which was first referred to as the square procedure, consists of enclosing the target lesion and safety margins within a geometric figure (in this case a square) and histologically examining the peripheral margins using paraffin-embedded sections.52,53 Studies on the Treatment of Lentigo Maligna Using Staged Surgical Excision