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The landscape of weight loss medication has been revolutionized by GLP-1 and dual GIP/GLP-1 receptor agonists
In the obese trial cohort, 1 mg moved 24-hour ambulatory heart rate by +0.7 bpm at week 24 the peak of the heart-rate curve, and below the placebo arms +0.8. In a healthy lean Phase 1 group, the same dose raised heart rate by about 10 bpm, with a peak near 15 to 20 bpm around days 4 to 6. Lean, younger participants had more reactive heart-rate control than the sedentary, obese, and metabolically stressed trial population
A few small studies have suggested that allulose may modestly increase postprandial GLP-1 levels when consumed with carbohydrates, potentially through mechanisms involving intestinal sensing of nutrients
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