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GLP-1 RAs regulate immune cell signaling, suppress proinflammatory cytokines (including tumor necrosis factor alpha (TNF), interleukin-6 (IL-6), and interleukin-1 beta (IL-1)), enhance anti-inflammatory cytokines (interleukin-10- (IL-10)), and decrease reactive oxygen species

Here we review evolving concepts of incretin action, focusing predominantly on GLP-1, from discovery, to clinical proof of concept, to therapeutic outcomes

Rejuvenation by Therapeutic Elimination of Senescent Cells

The FDA does not currently have guidelines on microdosing GLP-1 medications and its clear that more study is needed to understand the risks, benefits, and efficacy of doses that are lower than those recommended by current prescription guidelines