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Ghrelin not only triggers appetite but also plays a key role in fat metabolism and muscle preservation
Protein oxidation is another detrimental effect of elevated ROS levels
These results suggest the possibility that these GPCRs, including GLP-1R may have an important role in conditions where PSCs are activated such as AP/CP, and may contribute to the various changes seen with these diseases
PMID: 35761024 Cancer Immunol Immunother Targeting myeloperoxidase limits myeloid cell immunosuppression enhancing immune checkpoint therapy for pancreatic cancer
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