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To narrow down the region processed by this autoproteolytic cleavage we expressed the N-terminally truncated SnCE1 104-310 as wild type and catalytically dead SnCE1 C256A mutant protein (Supplementary Fig
The reasons are multifactorial: chronic inflammation damages blood vessel walls, corticosteroid use raises cholesterol and blood pressure, lupus-specific antibodies (particularly antiphospholipid antibodies) increase clotting risk, and the metabolic disruption caused by both the disease and its treatments creates a perfect storm for atherosclerosis
It is worth noting that Wegovy itself carries a low intrinsic risk of hypoglycaemia when used as monotherapy in patients without diabetes, as its glucose-lowering effects are glucose-dependent
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