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That said, there is one important caveat

NRF2 also cooperates with components of the transcriptional machinery (i.e., MED16) (Sekine et al, 2016), chromatin remodelers (i.e., BRG1) (Zhang et al, 2006) and chromatin-modifying enzymes (i.e., CBP) (Katoh et al, 2001) to drive target gene expression