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Oxidative stress activates microglia and reactive astrocytes, inducing inflammation, leading to cellular damage

Obesity-associated inflammation can accelerate NAD turnover through PARP-1 and CD38 pathways [85, 97, 116]

This means a fast system-wide response

Beyond T2D and weight management in individuals with overweight or obesity, GLP-1 receptor agonists are approved for metabolic dysfunction associated steatohepatitis in people with moderate or advanced fibrosis, obstructive sleep apnea in obese adults, reduction of major adverse cardiovascular events in adults with T2D and cardiovascular disease (CVD), and slowing progression of chronic kidney disease and cardiovascular mortality in adults with both chronic kidney disease and T2D