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IGF1R blockade with ganitumab results in systemic effects on the GH-IGF axis in mice
The ACR Convergence 2025 data specifically showed additive benefit when GLP-1 agonists were combined with DMARDs
This strategy not only effectively eradicates orthotopic and distal tumors but also enhances the bodys antitumor immune response, offering a promising new approach for CRC therapy
In addition, TG2 expression is upregulated in many cancer cells 9,10,11,12
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