After 3 min of habituation, mice were subjected to an electric foot shock (0.75 mA, 3 s) simultaneously to a tone (2.5 kHz, 85 dB, 3 s) and returned to their home cages
Tirzepatide's main disadvantages are the need for weekly injections, higher incidence of GI side effects compared to semaglutide, and cost
Proinflammatory cytokines, such as tumor necrosis factor-alpha (TNF-), interleukin-1 beta, and interferon-gamma (IFN-), promote ROS production, while ROS scavengers such as pyrrolidine dithiocarbamate and N-acetyl-cysteine (NAC) can reduce the ROS levels induced by these cytokines 14
Anso E, Mullen AR, Felsher DW, Mates JM, Deberardinis RJ, Chandel NS