The goal was to restore natural volume and improve skin texture using a stepwise, minimally invasive protocol tailored to the patients anatomical changes
Elliott J, Docherty N, Murphy C, Eckhardt H, Doyle S, Guinan E, et al
Acknowledgements ChatGPT was used in some places in the manuscript to suggest edits to the text and proper word usage and grammar
Studies also show that a ketogenic diet or BHB treatment can activate the major detoxification and oxidative stress nuclear factor erythroid 2-related factor 2 (Nrf2) pathway.53 In a spontaneous mouse model of T2D (db/db mice) treated with dapagliflozin, there was a noticeable reduction in the expression of genes related to oxidative stress compared with those treated with a standard vehicle or glimepiride.54 This reduction is associated with increased levels of BHB and NRF2 protein expression.54 Similarly, BHB treatment in human proximal tubular cells (HK-2) led to increased NRF2 expression and induced NRF2 nuclear translocation.55 Furthermore, a ketogenic diet has been reported to increase the expression of other antioxidants such as NAD(P)H dehydrogenase quinone I (NQO1) and superoxide dismutase (SOD1/2),56 and ameliorated paraquat (PQ)-induced elevated lipid peroxidation, toxicity, reduced antioxidant activity and decreased Nrf2 expression,57 highlighting its potential therapeutic role in combating oxidative stress and tissue hypoxia
